New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure.
نویسندگان
چکیده
Antibacteriophage antibiotics, RK-1441A and B, related to neothramycin were isolated from the culture broth of Streptomyces sp. and their structures were deduced from spectroscopic analyses. The structure of RK-1441A was 8,11-dihydroxy-3,7-dimethoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine. RK-1441B is a tautomeric mixture at C-3 of the structure, 3,8,11-trihydroxy-7-methoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine.
منابع مشابه
New pyrrolobenzodiazepine antibiotics, RK-1441A and B. I. Biological properties.
Streptomyces griseus and bacteriophage B were used for an assay system detecting anti-bacteriophage antibiotics. Streptomyces sp. RK-1441 was found to produce antibacteriophage antibiotics, RK-1441A and B, which are pyrrolo[1,4]benzodiazepine group antibiotics related to neothramycin. Both RK-1441A and B had antibacteriophage activity. The former showed antimicrobial activity on a hypersensitiv...
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ورودعنوان ژورنال:
- Agricultural and biological chemistry
دوره 54 11 شماره
صفحات -
تاریخ انتشار 1990