New pyrrolobenzodiazepine antibiotics, RK-1441A and B. II. Isolation and structure.

نویسندگان

  • H Osada
  • M Uramoto
  • J Uzawa
  • K Kajikawa
  • K Isono
چکیده

Antibacteriophage antibiotics, RK-1441A and B, related to neothramycin were isolated from the culture broth of Streptomyces sp. and their structures were deduced from spectroscopic analyses. The structure of RK-1441A was 8,11-dihydroxy-3,7-dimethoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine. RK-1441B is a tautomeric mixture at C-3 of the structure, 3,8,11-trihydroxy-7-methoxy-5-oxo-1H-pyrrolo[2,1-c:1,4]benzodiazepine.

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New pyrrolobenzodiazepine antibiotics, RK-1441A and B. I. Biological properties.

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عنوان ژورنال:
  • Agricultural and biological chemistry

دوره 54 11  شماره 

صفحات  -

تاریخ انتشار 1990